In the study, we identify changes in a group of individual metabolites, belonging to previously identified classes linked to active IBD: 21 for Crohn’s disease and 4 for Ulcerative colitis, including amino acids and derivatives, nucleotides and nucleosides, peptides, and an acyl-carnitine.
 
As the study is the first to identify metabolic changes in early life, our findings require further validation. However, if followed by further research, it will help expand our understanding of disease development and, potentially, uncover strategies for early detection or prevention of IBD in the future.

Authors

Jonas Rudbæk
Adam Koziol
Alice Fracchia
Madeleine Ernst
Aleksejs Sazonovs
Martin Woergaard Kjær
Nis Borbye-Lorenzen
Kristin Skogstrand
Tine Jess
Filip Ottosson