Utilizing a prospective birth cohort, the study aims at developing and validating prediction models to anticipate the risk of IBD and its subtypes, Crohn’s disease and ulcerative colitis, across all early life risk factors. 

Interestingly, we found that while the prediction of both Crohn’s disease and IBD overall was moderate, the prediction of ulcerative colitis was more accurate, particularly for younger-onset disease.

These data has a clinical application in prediction scores and risk stratification towards IBD prevention strategies and could inform the type and timing of intervention.

Authors

Manasi Agrawal
Anne Vinkel Hansen
Mette Julsgaard
Jean-Frederic Colombel
Tine Jess