Today, clinical practice is to only consider the most recent measurement for predicting disease development. In our study, while exploring inflammatory trajectories of patients with IBD, we show that information taken in previous samples hold valuable information as well.

Using longitudinal data on fecal calprotectin and C-reactive protein, we identify eight distinct types of trajectories that patients experience. 

Despite running the analyses separately, these trajectories are similar for both Danish and Scottish patients - and therefore provide a good foundation for follow-up studies aiming to generate an actual clinical tool for better decision-making during patient monitoring.

Authors

Nathan Constantine-Cooke
Marie Vibeke Vestergaard
Nikolas Plevris
Karla Monterrubio
Clara Ramos Belinchón
Solomon Ong
Alex Elford
Beatriz Gros
Aleksejs Sazonovs
Gareth-Rhys Jones
Tine Jess
Catalina Vallejos
Charlie Lees